|
The effect of skullcapflavon II, 5,2"-dihydroxy-6, 7, 8, 6’’-tetramethoxyflavone, on the growth of transplantable L1210 and sarcoma 180 tumors in mice was studied. Intraperitoneal treatment of skullcapflavon II caused a significant(T/C=166%) and a moderate (T/C-122%) prolongations of the life spans of ICR and BDF1 mice respectively, which had been intraperitoneally inoculated with sarcoma 180 and L1210 cells. Peritumoral injection of skullcapflavon II on the solid form of sarcoma 180 in mice inhibited the tumor growth strongly (Inhibition rate-71%).
|